The protein phosphatase 2A B '-regulatory subunit par1p is implicated in regulation of the S-pombe septation initiation network

Authors
Le Goff, X Buvelot, S Salimova, E Guerry, F Schmidt, S Cueille, N Cano, E Simanis, V
Citation
X. Le Goff et al., The protein phosphatase 2A B '-regulatory subunit par1p is implicated in regulation of the S-pombe septation initiation network, FEBS LETTER, 508(1), 2001, pp. 136-142
Citations number
31
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
ISSN journal
00145793 → ACNP
Volume
508
Issue
1
Year of publication
2001
Pages
136 - 142
Database
ISI
SICI code
0014-5793(20011109)508:1<136:TPP2B'>2.0.ZU;2-5
Abstract
In order to identify regulators of the Schizosaccharomyces pombe septation initiation network (SIN), which signals the onset of cell division, we have isolated extragenic suppressors of mutations in the GTPase spg1p, which is a central element in this pathway. One of these encodes the protein phosph atase 2A (PP2A) B'-regulatory subunit par1p. Loss of par1p function rescues mutants in cdc11. cdc7, and spg1, but no other SIN mutants. Our data sugge st that PP2A-par1p acts as a negative regulator of SIN signalling. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Scienc e B.V. All rights reserved.