The effects of propofol on normal and hypercholesterolemic isolated rabbitheart

The aim of the present study was to compare the effects of propofol on card iac contractile force in normal and hypercholesterolemic isolated rabbit he arts. While one group was fed with standard chow pellets (150 g/day), the o ther group received cholesterol (1% w/w) in addition to the same amount of rabbit chow pellets during 1 month. Hearts from standard-fed rabbits were g iven intralipid solvent or 25, 50 and 100 muM propofol by infusion. Hyperch olesterolemic rabbit hearts were administered 25, 50 and 100 muM propafol b y infusion. All concentrations of propofol did not result in any significan t change of the heart rates (HR) in two groups. Propofol (25, 50 and 100 mu M) infusion induced a concentration- and time-dependent inhibition in left ventricular pressure (LVP) in standard chow diet group (P < .05, .05 and .0 5, respectively). In hypercholesterolemic rabbit hearts, 25 and 50 muM prop ofol infusion developed a significant inhibition in LVP when compared with the standard chow diet group (P < .05 and .05, respectively). Propofol (100 muM) infusion developed a significant increase in LVP after 20 min in hype rcholesterolemic rabbit hearts when compared with normal rabbit hearts (P < .05). Supratherapeutic concentration of propofol might have cardioprotecti ve effect on hypercholesterolemic rabbit hearts. (C) 2001 Elsevier Science Inc. All rights reserved.