Cutaneous sclerosing Pacinian-like perineurioma

Aims: The term perineurioma has been used to designate a variety of clinica lly and histologically different proliferations of perineurial cells based on immunohistochemical and/or ultrastructural characterization. There are t wo different groups of neoplasms derived from perineurial cells: extraneura l or soft tissue perineuriomas, and intraneural perineuriomas. Recently, a sclerosing variant of cutaneous perineurioma has been described. Methods and results: We report a case of a cutaneous form of perineurioma. combining features of the intraneural and sclerosing varieties, as well as showing a Pacinian pattern of growth. In order to assess the neoplastic nat ure of the lesion. we performed fluorescence in-situ hybridization (FISH) a nalysis using a probe which maps to the chromosome band 22q11 and 22q13, al lowing us to show deletion or loss of one chromosome 22 in the tumour cells . Conclusions: This case may be considered a new variant of perineurioma with Pacinian-like features, for which we propose the designation 'sclerosing P acinian-like perineurioma'.