Over the past several decades, historians, geographers, demographers, anthr
opologists and others interested in the demographic effects of contact betw
een Europeans and Native Americans have emphasized epidemic diseases as a m
ajor factor in declining native populations. Little progress, however, has
been made toward developing a method and theory for testing hypotheses rega
rding epidemic diseases and depopulation in the archaeological record. Tath
am Mound, an early contact period mortuary locality in Florida serves as us
eful example of the difficulties encountered when testing propositions rega
rding epidemic disease in archaeological context.