This article addresses the relations between 'nature' and 'culture' (and th
ose characteristics associated with 'the natural' and 'the cultural') in th
e context of the debates about Prozac. Following Marilyn Strathern, I focus
specifically on the contested issue of enablement - that is, on what Proza
c does or does not enable, and on the relation between enablement and enhan
cement, normality and pathology. I argue that the implications of the model
of the brain that accompanies explanations of Prozac are such that comment
ators are obliged to address not only the nature of normality but also the
nature of nature itself. Through a close analysis of these debates, I sugge
st that critiques of Prozac should be understood not as objections to reduc
tionism - to a biology that closes things down - but rather to one that ope
ns things up: that opens up the relations between nature, culture, biology
and the individual, relations that are now cross-cut and thrown about by ar
tificiality. Objections to Prozac, then, might be characterized as an attem
pt to put these concepts back into their 'proper' positions, to re-establis
h the relationality between them. In conclusion, I argue that the biology p
ut forward by proponents of psychopharmacology, regardless of the desirabil
ity of the latter, challenges not only the frequent assumptions that are ma
de about the claims of materialist science, but also some of the terms and
concepts that are commonly deployed in the social sciences.