T cell immunotherapeutic populations control viral infections in bone marrow transplant recipients

Immunotherapies designed to prevent infection serve as an increasingly impo rtant adjunct to bone marrow transplantation (BMT). T cell immunotherapies are particularly useful for the control of virus infections, provided that T cell populations are free of graft-vs-host (GVH) activity. In this review . we describe positive and negative selection methods with which donor T ce ll populations devoid of GVH activity can be prepared for transfer to the i mmunodeficient BMT recipient. The support of patients with T cell immunothe rapies may ultimately revolutionize BMT, elevating the procedure from a sal vage to a front-line treatment strategy for otherwise fatal disorders.