A new total synthesis of (+/-)- pisiferic acid

Authors
Gupta, PD Pal, A Mukherjee, D
Citation
Pd. Gupta et al., A new total synthesis of (+/-)- pisiferic acid, I J CHEM B, 40(11), 2001, pp. 1033-1035
Citations number
11
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
40
Issue
11
Year of publication
2001
Pages
1033 - 1035
Database
ISI
SICI code
0376-4699(200111)40:11<1033:ANTSO(>2.0.ZU;2-I
Abstract
Starting from 6-isopropyl-7-methoxy-1-tetralone 2, a new synthesis of (+/-) -pisiferic acid 1 has been achieved. The salient features of the present sy nthesis are (i) facile conversion of 2 into the cis-fused octahydrophenanth renone 5, (ii) efficient transformation of 5 into the triester 7, and (iii) conversion of 7 into 1 involving Dieckmann cyclisation as a key reaction.