A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977

Authors
Dixon, DJ Ley, SV Reynolds, DJ Chorghade, MS
Citation
Dj. Dixon et al., A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977, I J CHEM B, 40(11), 2001, pp. 1043-1053
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
40
Issue
11
Year of publication
2001
Pages
1043 - 1053
Database
ISI
SICI code
0376-4699(200111)40:11<1043:ASAESS>2.0.ZU;2-7
Abstract
A short and efficient synthesis of the potent 5-lipoxygenase inhibitor CMI- 977 has been accomplished, utilising an oxygen to carbon rearrangement of a n anomerically linked alkynyl stannane tetrahydrofuranyl ether derivative a s the key step.