Limited mycobacterial infection of the liver as a consequence of its microanatomical structure causing restriction of mycobacterial growth to professional phagocytes

Authors
Seiler, P Schwendener, RA Bandermann, S Brinkmann, V Grode, L Kaufmann, SHE Aichele, P
Citation
P. Seiler et al., Limited mycobacterial infection of the liver as a consequence of its microanatomical structure causing restriction of mycobacterial growth to professional phagocytes, INFEC IMMUN, 69(12), 2001, pp. 7922-7926
Citations number
38
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
12
Year of publication
2001
Pages
7922 - 7926
Database
ISI
SICI code
0019-9567(200112)69:12<7922:LMIOTL>2.0.ZU;2-W
Abstract
Among sites of extrapulmonary growth of Mycobacterium tuberculosis, the liv er is the least infected. Our data suggest that this is due to the complete restriction of mycobacterial growth to liver macrophages. Unlike in organs more persistently seeded by AL tuberculosis, in the liver the bacteria do not infect cell types other than professional phagocytes.