Improvement of anti-Hu-associated paraneoplastic sensory neuropathy after chemoradiotherapy in a small cell lung cancer patient

A 66-year-old man developed progressive painful dysesthesia in his hands an d feet over 3 months. His vibration sense was impaired and sensory nerve ac tion potentials of the limbs were not evoked. Biopsy of the peroneal nerve revealed sensory neuropathy. Positive anti-Hu antibody facilitated delineat ion of a right hilar mass and a metastatic lymph node in thoracic CT scan. He was diagnosed as small cell lung cancer associated with paraneoplastic s ensory neuropathy. A complete response was achieved through chemotherapy (c arboplatin and etoposide) and subsequent radiation therapy. Notably, his ne urological conditions, although not changed during the hospitalization, gra dually improved afterwards.