SYNTHESIS OF VINCA ALKALOIDS AND RELATED-COMPOUNDS .84. SULFONAMIDE DERIVATIVES OF SOME VINCA ALKALOIDS WITH CARDIOVASCULAR ACTIVITY

Authors
MOLDVAI I TEMESVARIMAJOR E SZANTAY C TOTH G KARPATI E SZANTAY C
Citation
I. Moldvai et al., SYNTHESIS OF VINCA ALKALOIDS AND RELATED-COMPOUNDS .84. SULFONAMIDE DERIVATIVES OF SOME VINCA ALKALOIDS WITH CARDIOVASCULAR ACTIVITY, Archiv der pharmazie, 330(6), 1997, pp. 190-198
Citations number
24
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
330
Issue
6
Year of publication
1997
Pages
190 - 198
Database
ISI
SICI code
0365-6233(1997)330:6<190:SOVAAR>2.0.ZU;2-6
Abstract
(+)-Vincamine (1) and (+)-vinpocetine (2) were chlorosulfonylated and the resulting sulfonyl chloride isomers (3-6) were transformed into su lfonamides (7-10). The ester group of sulfonamides was modified by sel ective hydrolysis and transesterification. Apovincaminol derivatives ( 14-16) were also prepared by reduction. In addition to the known cereb rovascular effects of the unsubstituted compounds (1, 2), sulfonamides also show a significant peripheral vasodilator effect.