TREATMENT OF BOVINE MASTITIS WITH HOUTTUYNIN SODIUM BISULFATE

Houttuynin sodium bisulphate (HSB), alpha hydroxyl-capryl-ethyl-sodium -sulphonate, is a product formed by reacting sodium bisulphate with ho uttuynin, which is obtained from a medicinal herb Houttuynia cordata T hunb. From HBS an aqueous intramammary solution was made for the treat ment of bovine clinical mastitis. A total of 104 acute and subacute ma stitis cases were randomly assigned into two groups with 52 cases in e ach group: 1. an HSB group in which 80 mg HSB was infused into an affe cted gland; and 2. a PS group in which intramammary administration of 800000 i.u. penicillin G in combination with Ig of streptomycin (PS) w as conducted. The treatments were administered twice daily until the i nflammatory signs were eliminated and mammary secretion became normal. In acute mastitis, 88.2% (15 of 17) were clinically cured and 52.9% ( nine of 17) microbiologically cured by HSB; in the PS group, 90.0% (18 of 20) were clinically cured and 55.0% (11 of 20) microbiologically c ured. In subacute cases, the clinical and microbiological cure rates w ere 94.3% (33 of 35) and 45.7% (16 of 35) respectively, in the HSB gro up; and in the PS group the clinical and microbiological cure rates we re 93.7% (30 of 32) and 43.8% (14 of 32), respectively. No statistical ly significant difference was found between HSB and PS groups in the t reatment of acute as well as subacute mastitis. In addition, an inhibi tory effect was found on the growth of lactic streptococcus in the mil l; collected within 48 h of intramammary treatment with penicillin G i n combination with streptomycin. However, for HSB, a mild inhibitory e ffect on lactic streptococci was detected in the milli within 12h of t reatment.