Splenic nodules and sickle cell anaemia

Objective. We report 4 patients with sickle cell anemia presenting with int ra-splenic benign nodules corresponding to islands of preserved tissue with in splenic ferro-calcinosis. Material and methods. Ultrasound, CT and MRI findings were evaluated and co mpared to a follow-up study by ultrasound and CT done after 6 to 12 months. Results. Ultrasound showed multiple well-defined rounded nodules appearing hypoechoic compared to the rest of the spleen that was hyperechoic. On CT, the nodules were homogenous, hypodense relative to the spleen, isodense to the liver in 3 cases and hypodense to the liver in 1 case. On MRI, the nodu les appeared relatively hyperintense within low-signal-intensity spleens. T he ultrasound and CT follow-up study demonstrated no remarkable change. Conclusion. In sickle cell patients, intra-splenic benign nodules correspon ding to normal splenic tissue may be identified on imaging studies. The dif ferential diagnosis is discussed.