Dis1/TOG universal microtubule adaptors - one MAP for all?

Microtubules play central roles in various cellular processes in eukaryotes . The dynamics and organisation of interphase microtubules and mitotic spin dles are dramatically altered during the cell cycle and development. Howeve r, the molecular mechanisms underlying this dynamic behaviour remain to be understood. In recent years, a novel family of microtubule-associated prote ins (MAPs), the Dis1/TOG family, has emerged as a versatile regulator of mi crotubule function. These MAPs are highly conserved in eukaryotes from yeas ts and plants to humans. The localisation and function of these MAN are rio t determined simply by their intrinsic microtubule-binding activity. Instea d this family executes its diverse roles by interacting with other regulato ry molecules, including microtubule motors and centrosomal proteins. The mo dular structure of these MAN may allow them to interact with multiple prote ins and thereby be involved in a wide variety of microtubule and spindle fu nctions.