ARTHROGRYPOSIS MULTIPLEX CONGENITA - ETIOLOGY, GENETICS, CLASSIFICATION, DIAGNOSTIC-APPROACH, AND GENERAL-ASPECTS

Arthrogryposis is a sign associated with many specific conditions and syndromes. It is a term used to describe the presence of multiple join t contractures that are present at birth. It can be seen in isolation or in association with other congenital abnormalities as part of a syn drome with or without central nervous system involvement. The exact pa thogenesis of arthrogryposis is unknown, but all involve fetal akinesi a (decreased fetal movement) with subsequent joint contractures. In th is article I describe the causes, genetic aspects, classification, and approach to diagnosis.