One-dimensional DOSY

A new NMR experiment for correlating diffusion coefficients and chemical sh ifts is presented. This experiment provides the same information as the con ventional DOSY experiment, but only requires a single dimension because a n onuniform magnetic field gradient is used to encode the diffusion informati on into the lineshapes of the peaks in the chemical shift dimension. By fit ting the resulting lineshapes, the diffusion coefficient for each peak in t he spectrum can be extracted. Using this experiment, a qualitative DOSY spe ctrum can be generated using the results from a single one-dimensional expe riment. Quantitative results can be determined with the use of reference ex periments. (C) 2001 Academic Press.