Proton MRI of C-13 distribution by J and chemical shift editing

Citation
C. Casieri et al., Proton MRI of C-13 distribution by J and chemical shift editing, J MAGN RES, 153(1), 2001, pp. 117-123
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MAGNETIC RESONANCE
ISSN journal
10907807 → ACNP
Volume
153
Issue
1
Year of publication
2001
Pages
117 - 123
Database
ISI
SICI code
1090-7807(200111)153:1<117:PMOCDB>2.0.ZU;2-5
Abstract
The sensitivity of C-13 NMR imaging can be considerably favored by detectin g the H-1 nuclei bound to C-13 nuclei via scalar J-interaction (X-filter). However, the J-editing approaches have difficulty in discriminating between compounds with similar J-constant as, for example, different glucose metab olites. In such cases, it is almost impossible to get J-edited images of a single-compound distribution, since the various molecules are distinguishab le only via their chemical shift. In a recent application of J-editing to h igh-resolution spectroscopy, it has been shown that a more efficient chemic al selectivity could be obtained by utilizing the larger chemical shift ran ge of C-13. This has been made by introducing frequency-selective C-13 puls es that allow a great capability of indirect chemical separation. Here a do uble-resonance imaging approach is proposed, based on both J-editing and C- 13 chemical shift editing, which achieves a powerful chemical selectivity a nd is able to produce full maps of specific chemical compounds. Results are presented on a multicompartments sample containing solutions of glucose an d lactic and glutamic acid in water. (C) 2001 Academic Press.