M. Koufaki et al., Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias, J MED CHEM, 44(24), 2001, pp. 4300-4303
A series of new compounds that contain lipoic acid and trolox connected thr
ough spacers were synthesized and examined for their antioxidant activity a
nd their protective effects against reperfusion arrhythmias in isolated hea
rt preparations. All compounds tested are strong inhibitors of lipid peroxi
dation. in rat liver microsomal membranes induced by ferrous ions and ascor
bate. N-(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carbon
yl)-N'-(1,2-dithiolane-3-pentanoyl)-1,2-phenylenediamine (13) exhibits anti
-lipid peroxidation activity at the nanomolar range. N-(3,4-Dihydro-6-hydro
xy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carbonyl)-N'-(1,2-dithiolane-3-pen
tanoyl)ethylenediamine (10) and 13 totally suppressed reperfusion arrhythmi
as.