Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias

Citation
M. Koufaki et al., Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias, J MED CHEM, 44(24), 2001, pp. 4300-4303
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
00222623 → ACNP
Volume
44
Issue
24
Year of publication
2001
Pages
4300 - 4303
Database
ISI
SICI code
0022-2623(20011122)44:24<4300:NPIOLP>2.0.ZU;2-L
Abstract
A series of new compounds that contain lipoic acid and trolox connected thr ough spacers were synthesized and examined for their antioxidant activity a nd their protective effects against reperfusion arrhythmias in isolated hea rt preparations. All compounds tested are strong inhibitors of lipid peroxi dation. in rat liver microsomal membranes induced by ferrous ions and ascor bate. N-(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carbon yl)-N'-(1,2-dithiolane-3-pentanoyl)-1,2-phenylenediamine (13) exhibits anti -lipid peroxidation activity at the nanomolar range. N-(3,4-Dihydro-6-hydro xy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carbonyl)-N'-(1,2-dithiolane-3-pen tanoyl)ethylenediamine (10) and 13 totally suppressed reperfusion arrhythmi as.