Mq. Wang et al., Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium), J PHARM PHA, 53(11), 2001, pp. 1515-1523
The activity of CVT-E002, an aqueous extract containing mainly oligosacchar
ides and polysaccharides from North American ginseng (Panax quinquefolium),
as an immunobooster on murine spleen cells and peritoneal macrophages, was
studied in-vitro. CVT-E002 stimulated the proliferation of normal mouse sp
leen cells, of which the major responding subpopulation was identified as B
lymphocytes. CVT-E002 also activated peritoneal exudate macrophages leadin
g to enhanced interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis f
actor-alpha (TNF-alpha) and nitric oxide (NO) production. In addition, CVT-
E002 stimulated in-vivo immunoglobulin G (IgG) production in treated mice.
These results identify some of the immunomodulating activities of CVT-E002
and suggest its use clinically for the modulation of immune responses.