Noninvasive cardiac output by partial CO2 rebreathing after severe chest trauma

Background: In multiple trauma patients, early continuous cardiac output (C CO) monitoring is frequently desired but is difficult to routinely employ i n most emergency departments because it requires invasive procedures. Recen tly, a noninvasive cardiac output (NICO) technique based on the Fick princi ple and partial CO2 rebreathing has shown promise under a variety of condit ions. Since this method has not been tested after lung damage, we evaluated its utility in a clinically relevant model. Methods: Anesthetized, ventilated swine (n = 11, 35-45 kg) received a unila teral blunt trauma via a captive bolt gun followed by a 25% hemorrhage. Aft er 60 min of shock, crystalloid resuscitation was given as needed to mainta in heart rate < 100 beats/min and mean arterial pressure > 70 min Hg. Stand ard CCO by thermodilution (Baxter Vigilance, Irvine, CA) was compared with NICO (Novametrix Medical Systems Inc., Wallingford, CT) for 8 hr. Results: The severity of the injury is reflected by seven deaths (average s urvival time = 4.25 hr). Trauma increased dead space ventilation (19%), air way resistance (30%), and lactate (3.2 mmol/L), and decreased dynamic compl iance (48%) and Pao(2)/FIO2 (54%). In these extreme conditions, the time co urse and magnitude of change of CCO and NICO were superimposed. Bland-Altma n analysis reveal a bias and precision of 0.01 +/- 0.69 liters/min. The lin ear relationship between individual CCO and NICO values was significant (p < 0.0001) and was described by the equation NICO = (0.74 +/- 0.1)CCO + (0.6 5 +/- 0.16 liters/min) but the correlation coefficient (r(2) = 0.541) was r elatively low. The cause for the low correlation could not be attributed to increased pulmonary shunt, venous desaturation, anemia, hypercapnia, incre ased dead space ventilation, or hyperlactacidemia. Conclusion: NICO correlated with thermodilution CCO, but underestimated thi s standard by 26% in extreme laboratory conditions of trauma-induced cardio pulmonary dysfunction; 95% of the NICO values fall within 1.38 liters/min o f CCO; and with further improvements, NICO may be useful in multiple trauma patients requiring emergency intubation during initial assessment and work up.