Background: Trans-sodium crocetinate (TSC) has been shown to increase oxyge
n consumption during hemorrhagic shock. The current study was done to deter
mine the effect of TSC on other parameters such as blood pressure, heart ra
te, blood pH, and lactate.
Methods: A rat model of hemorrhagic shock was used, in which a constant vol
ume of blood is removed. did not decrease as much when TSC was given, and p
lasma lactate levels were greatly reduced.
Results: TSC increased mean arterial blood pressure from a value (immediate
ly after hemorrhage) of 35 min Hg to a value of 75 min Hg, and all treated
animals survived. In contrast, blood pressure in control animals decreased,
with most dying soon after the hemorrhage. TSC also lessened the tachycard
ia which resulted from the hemorrhage. Blood pH.
Conclusion: It would appear that TSC is a promising initial treatment for h
emorrhagic shock.