Trans-sodium crocetinate restores blood pressure, heart rate, and plasma lactate after hemorrhagic shock

Background: Trans-sodium crocetinate (TSC) has been shown to increase oxyge n consumption during hemorrhagic shock. The current study was done to deter mine the effect of TSC on other parameters such as blood pressure, heart ra te, blood pH, and lactate. Methods: A rat model of hemorrhagic shock was used, in which a constant vol ume of blood is removed. did not decrease as much when TSC was given, and p lasma lactate levels were greatly reduced. Results: TSC increased mean arterial blood pressure from a value (immediate ly after hemorrhage) of 35 min Hg to a value of 75 min Hg, and all treated animals survived. In contrast, blood pressure in control animals decreased, with most dying soon after the hemorrhage. TSC also lessened the tachycard ia which resulted from the hemorrhage. Blood pH. Conclusion: It would appear that TSC is a promising initial treatment for h emorrhagic shock.