Background. Diagnosis of iron deficiency in hemodialysis patients is limite
d by the inaccuracy of commonly used tests. Reticulocyte hemoglobin content
(CHr) is a test that has shown promise for improved diagnosis in prelimina
ry studies. The purpose of this study was to compare iron management guided
by serum ferritin and transferrin saturation to management guided by CHr.
Methods: A total of 157 hemodialysis patients from three centers were rando
mized to iron management based on (group 1) serum ferritin and transferrin
saturation, or (group 2) CHr. Patients were followed for six months. Treatm
ent with intravenous iron dextran, 100 mg for 10 consecutive treatments was
initiated if (group 1) serum ferritin < 100 ng/mL or transferrin saturatio
n < 20%, or (group 2) CHr < 29 pg.
Results. There was no significant difference between groups in the final me
an hematocrit or epoetin dose. The mean weekly dose of iron dextran was 47.
7 +/- 35.5 mg in group 1 compared to 22.9 +/- 20.5 mg in group 2 (P = 0.02)
. The final mean serum ferritin was 399.5 +/- 247.6 ng/mL in group 1 compar
ed to 304.7 +/- 290.6 ng/mL in group 2 (P < 0.05). There was no significant
difference in final TSAT or CHr. Coefficient of variation was significantl
y lower for CHr than serum ferritin and transferrin saturation (3.4% vs. 43
.6% and 39.5%, respectively).
Conclusions. CHr is a markedly more stable analyte than serum ferritin or t
ransferrin saturation, and iron management based on CHr results in similar
hematocrit and epoetin dosing while significantly reducing IV iron exposure
.