Eradication of Helicobacter pylori and improvement of hereditary angioneurotic oedema

Citation
H. Farkas et al., Eradication of Helicobacter pylori and improvement of hereditary angioneurotic oedema, LANCET, 358(9294), 2001, pp. 1695-1696
Citations number
5
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
358
Issue
9294
Year of publication
2001
Pages
1695 - 1696
Database
ISI
SICI code
0140-6736(20011117)358:9294<1695:EOHPAI>2.0.ZU;2-8
Abstract
Helicobacter pylori infection is thought to be a causal factor in various d ermatological disorders.,We assessed the frequency of H pylori infection in 65 patients with hereditary angioneurotic oedema. We measured the serum co ncentration of antibodies against H pylori and did the carbon-14-urease bre ath test in patients with positive H pylori serology. 19 of 65 patients had H pylori infection. All patients with infection, and 11 of 46 without infe ction, had a history of recurrent episodes of acute abdominal pain. We succ essfully eradicated H pylori infection in IS patients. The frequency of abd ominal symptoms was significantly higher in the Infected group (p=0.002 aft er adjustment for age). In nine of 19 patients with dyspepsia, the frequenc y of oedematous episodes decreased from 100 over 10 months before eradicati on to 19 during the 10-month follow-up period. Screening for, and eradicati on of, H pylori infection seems to be justified in patients with hereditary angioneurotic oedema.