High spatial resolution in vivo 2D H-1 magnetic resonance spectroscopic imaging of human muscles with a band-selective technique

This report demonstrates a 2D H-1 magnetic resonance spectroscopic imaging (MRSI) technique that can address some technical difficulties often encount ered in MRS studies of human muscles. A preliminary application of this who le-slice technique in human skeletal muscles demonstrates clearly noticeabl e differences in H-1 metabolite spectra between different human muscles. Th is observation illustrates the importance of multi-voxel and high spatial r esolution in a heterogeneous environment. This technique is robust, can be easily implemented on a commercial MR scanner, and should prove useful for investigators in both basic and clinical H-1 MRS studies. (C) 2001 Elsevier Science Inc. All rights reserved.