Expression of alpha tubulin during the dimorphic transition of Paracoccidioides brasiliensis

In this study we analyzed the expression of alpha -tubulin during the dimor phic transition of the human-pathogenic fungus Paracoccidioides brasiliensi s. The alpha -tubulin from P. brasiliensis was recognized by a commercially available anti-tubulin antibody and was developmentally regulated during t he dimorphic form transition. We detected at least two alpha -tubulin isofo rms in the mycelial state and only one isoform in the yeast forms. This fin ding suggests specific roles for the alpha -tubulin isoforms in P. brasilie nsis's yeast and mycelial forms.