In vivo selection of oxacillinase-mediated ceftazidime resistance in Pseudomonas aeruginosa

Authors
Leotard, S Poirel, L Leblanc, PE Nordmann, P
Citation
S. Leotard et al., In vivo selection of oxacillinase-mediated ceftazidime resistance in Pseudomonas aeruginosa, MICROB DR R, 7(3), 2001, pp. 273-275
Citations number
11
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE
ISSN journal
10766294 → ACNP
Volume
7
Issue
3
Year of publication
2001
Pages
273 - 275
Database
ISI
SICI code
1076-6294(200123)7:3<273:IVSOOC>2.0.ZU;2-E
Abstract
Ceftazidime-susceptible and -resistant Pseudomonas aeruginosa strains were isolated from pulmonary specimens following a treatment with ceftazidime in a patient who developed a nosocomial pneumonia. The ceftazidime-susceptibl e and -resistant strains were clonally related and harbored a self-transfer able similar to 155-kb plasmid. These isolates expressed two OXA-10-like ox acillinases, the narrow-spectrum OXA-35 and the expanded-spectrum OXA-19, r espectively, differing by one amino acid substitution. This is the first ex ample of in vivo selection of an extended-spectrum oxacillinase from a rest ricted-spectrum oxacillinase.