Phenytoin hypersensitivity syndrome

Phenytoin hypersensitivity syndrome (PHS) is a rare, and important entity c haracterized by rash, fever, lymphadenopathy, leukocytosis with atypical ly mphocytes, eosinophilia and associated hepatitis. In this article, we prese nt the clinical, laboratory and histopathologic results of 5 cases of PHS. In therapy, pheyntoin was stopped and sodium valproate (10-20 mg/kg day) wa s started. Additionally, prednisolone was given in two patients who had not resolved eruption with conservative therapy.