Seizures in family members of patients with hippocampal sclerosis

Objective: To characterize seizures in family members of patients with refr actory temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS). Methods : The authors systematically investigated family history (FH) of seizures i n 66 probands with histologically proven HS, and in 51 control subjects. A positive FH was defined as at least one first-to-third-degree relative bein g affected. The odds ratio (OR) to be affected with seizures was calculated for siblings, parents, and aunts/uncles. Results: An FH of seizures was fo und in 58% of patients, and in 24% of control subjects (p = 0.02). A variet y of seizure types were found. Siblings of patients were more likely to be affected than siblings of control subjects (OR 11.5; 95% CI = 1.5 to 86.9 p = 0.003), with febrile convulsions occurring in 5.8% of the siblings of pa tients. The OR of being affected was 5.7 for parents of patients, and 1.9 f or aunts/uncles of patients (p = NS). Conclusion: FH of seizures, particula rly febrile convulsions, are a risk factor for TLE with HS. These data sugg est that a variety of genes contributing to epilepsy phenotypes in relative s may be involved in the pathogenesis of HS.