Polymorphisms in hypocretin/orexin pathway genes and narcolepsy

Authors
Olafsdottir, BR Rye, DB Scammell, TE Matheson, JK Stefansson, K Gulcher, JR
Citation
Br. Olafsdottir et al., Polymorphisms in hypocretin/orexin pathway genes and narcolepsy, NEUROLOGY, 57(10), 2001, pp. 1896-1899
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
57
Issue
10
Year of publication
2001
Pages
1896 - 1899
Database
ISI
SICI code
0028-3878(20011127)57:10<1896:PIHPGA>2.0.ZU;2-8
Abstract
The neuroexcitatory peptide hypocretin and its receptors are central to the pathophysiology of both human and animal models of the disease. In this st udy of American and Icelandic patients with narcolepsy, the authors found n o significant association between narcolepsy and single-nucleotide polymorp hisms in the genes for hypocretin or its two known receptors, hypocretin re ceptor-1 and hypocretin receptor-2.