Twelve patients with a catastrophic reaction (CR) (an outburst of frustrati
on, depression, and anger when confronted with a task) were identified in a
prospective cohort population (n = 326) with first-ever stroke admitted wi
thin 48 hours from onset. The authors' findings suggest that CR is a rare t
hough not exceptional phenomenon in acute stroke and is associated with non
fluent aphasias and left opercular lesions. CR, poststroke depression, and
emotionalism are distinct but related disorders.