A new autosomal dominant pure cerebellar ataxia

A kindred is described with a dominantly inherited "pure" cerebellar ataxia in which the currently known spinocerebellar ataxias have been excluded. I n the eight subjects studied, a notable clinical feature is slow progressio n, with the three least affected having only a mild degree of gait ataxia a fter three or more decades of disease duration. Pending an actual chromosom al locus discovery, the name spinocerebellar ataxia (SCA)15 is expectantly applied.