Apolipoprotein E and age at onset of Alzheimer's disease in African American patients

Authors
Goldstein, FC Ashley, AV Gearing, M Hanfelt, J Penix, L Freedman, LJ Levey, AI
Citation
Fc. Goldstein et al., Apolipoprotein E and age at onset of Alzheimer's disease in African American patients, NEUROLOGY, 57(10), 2001, pp. 1923-1925
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
57
Issue
10
Year of publication
2001
Pages
1923 - 1925
Database
ISI
SICI code
0028-3878(20011127)57:10<1923:AEAAAO>2.0.ZU;2-0
Abstract
The authors examined whether the APOE-epsilon4 allele is associated with an earlier age at onset of AD in 71 African American patients with probable A D. The authors found a linear dose effect in which each copy of the epsilon 4 allele was associated with a 3.6-year earlier onset of AD, indicating a d ose-dependent relationship between APOE-epsilon4 and age at onset of AD in African Americans.