Do NMDA receptor kinetics regulate the end of critical periods of plasticity?

Authors
Medina, AE Liao, DS Mower, AF Ramoa, AS
Citation
Ae. Medina et al., Do NMDA receptor kinetics regulate the end of critical periods of plasticity?, NEURON, 32(4), 2001, pp. 553-555
Citations number
14
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEURON
ISSN journal
08966273 → ACNP
Volume
32
Issue
4
Year of publication
2001
Pages
553 - 555
Database
ISI
SICI code
0896-6273(20011120)32:4<553:DNRKRT>2.0.ZU;2-8
Abstract
Increasing NR2A subunit expression and the associated shortening of the NMD A-EPSC are thought to underlie the loss of diverse types of sensory cortica l plasticity. Lu and colleagues (Lu et al., 2001 [this issue of Neuron]) no w report that mice lacking the NR2A subunit display normal duration of crit ical periods of barrel cortex plasticity. Shortening of the NMDA-EPSC is th erefore not responsible for the end of these critical periods.