TREATMENT OF PULMONARY FIBROSIS WITH CYCL OSPORINE - REPORT OF 3 CASES

There are few reports on the use of cyclosporine In idiopathic pulmona ry fibrosis, in experimental animals or humans. We report three patien ts with advanced pulmonary fibrosis in whom steroid therapy failed and that received cyclosporine in a dose of 3 to 5 mg/kg for three to fiv e months. One patient developed systemic hypertension that subsided re ducing the dose of cyclosporine. No positive changes in dyspnea were o btained and pulmonary function tests deteriorated during the treatment period. We conclude that cyclosporine treatment had no clinical benef it in these patients with pulmonary fibrosis.