Lbd. Hinds et al., Increased immunoglobulin secretion by B lymphocytes from Trypanosoma cruziinfected mice after B lymphocytes-natural killer cell interaction, PARASITE IM, 23(11), 2001, pp. 581-586
In the present study, we investigated whether natural killer (NK) cells mod
ulate immunoglobulin (Ig) secretion by B cells from Trypanosoma cruzi-infec
ted mice. B cells from infected mice increased IgM and IgG2a secretion in t
he presence of a NK cell line, and this response was cell contact-dependent
. Stimulation of splenic B cells with polyinosinic-polycytidylic acid, a NK
cell activator, also increased Ig secretion by B cells from infected mice.
B cells from infected mice expressed higher levels of the B7.2 molecule. O
ur results suggest that NK cells may be involved in the control of the abno
rmal B cell activation observed during T. cruzi infection.