Activity of the cyclic depsipeptide emodepside (BAY 44-4400) against larval and adult stages of nematodes in rodents and the influence on worm survival

The present investigations deal with the activity of the cyclic depsipeptid e emodepside (BAY 44-4400) against larval and adult stages of three rodent nematodes. While emodepside acts strongly against the adult stages of the r at nematodes Nippostrongylus brasiliensis and Strongyloides ratti, as well as against the mouse nematode Heligmosomoides polygyrus, its actions agains t the larval stages of these nematodes vary according to the species. Thus. , emodepside is highly effective against the lung and intestine larval stag es of N. brasiliensis and S. ratti. By contrast, the larval stages of H. po lygyrus in the intestine are only partly affected by higher emodepside dosa ges.