Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19

Citation
Smg. Hoffman et al., Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19, PHARMACOGEN, 11(8), 2001, pp. 687-698
Citations number
86
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMACOGENETICS
ISSN journal
0960314X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
687 - 698
Database
ISI
SICI code
0960-314X(200111)11:8<687:OSAEOT>2.0.ZU;2-I
Abstract
The cytochrome P450 superfamily of mixed-function oxygenases has been exten sively studied due to its many critical metabolic roles, and also because i t is a fascinating example of gene family evolution. The cluster of genes o n human chromosome 19 from the CYP2A, 2B, and 2F subfamilies has been previ ously described as having a complex organization and many pseudogenes. We d escribe the discovery of genes from three more CYP2 subfamilies inside the cluster, and assemble a complete map of the region. We comprehensively revi ew the organization, structure, and expression of genes from all six subfam ilies. A general hypothesis for the evolution of this complex gene cluster is also presented. Pharmacogenetics 11:687-698 (C) 2001 Lippincott Williams & Wilkins.