N1-phenyl substituted 4-quinolones of tuberculostatic activity

Various different substituted N1-phenyl-6-fluoro-7-piperazinyl-4-quinolone 3-carboxylates and the diazoniumtetrafluoroborate of sparfloxacin were test ed for their ability to inhibit the growth of various Mycobacterium strains of different origin. The N1-p-hydroxylphenyl substituted compound 22 and t he methoxyphenyl substituted compound missing the piperazine ring 12 were i dentified as promising candidates for the further development of an improve d treatment of tuberculosis. In addition, compound 22 and the N1-p-fluoroph enyl substituted analogue 4 were found to be active against Mycobacterium a vium, which is often isolated from patients suffering from ADDS.