Spray-dried diclofenac-loaded poly(epsilon-caprolactone) nanocapsules and nanospheres. Preparation and physicochemical characterization

The aims of the present study were to prepare spray-dried polymeric nanocap sules (NC) and nanospheres (NS) from poly (epsilon -caprolactome) (P epsilo nC) suspensions containing diclofenac (DIC) and to determine the physicoche mical properties of the formulations. NC or NS suspensions were prepared by interfacial deposition of the polymer. DSC-thermograms of raw materials an d NC or NS suspensions (evaporated or spray-dried) were obtained using a PL -DSC. Spray-dried powders were prepared by addition of 3% (w/v) Aerosil(R) 200 into suspensions of NC or NS. These mixtures were fed into a spray-drye r. DIC was assayed by HPLC. NC and NS spray-dried powders were examined und er SEM (Jeol Scanning Microscope, JSM-5800). NC and NS suspensions had acce ptable diameter, 340 and 247 nm respectively. The yields of NC and NS spray -dried powders were 80% and 75% and the recovery of the DIC was 99% and 93% , respectively. The melting peak of P epsilonC in NC and NS was observed at a temperature about 10 degreesC lower than in the raw material. In the NC thermograms the maximum of the oil (Miglyol 810(R)) melting peak (+1.6 degr eesC) was lowered about 7 degreesC. For spray-dried NC formulations, the SE M analyses of powders showed spherical microparticles of silicon dioxide, c overed by nanoparticles (300 nm), while for spray-dried NS formulations the microparticles presented a rugged surface at the same magnification.