Anticonvulsant and neurotoxicity evaluation of 5-(un)-substituted isatinimino derivatives

Various Schiff bases were prepared by reacting 5-(un)-substituted isatin wi th some heterocyclic compounds, viz., N-[4-(4'-chloropherlyl-thiazol-2-yl] semicarbazide, 3-amino-2-methylmercaptoquinazolin-4-one, 3-(4'-pylidyl)-4-a mino-5-mercapto-4(H)-1,2,4-triazole and 4-(4'-chlorophenyl)-6-(4"-methylphe nyl)-2-aminopyrimidine. The compounds were evaluated for anticonvulsant and neurotoxic properties. The compound 3-(3',4'-dihydro-2'-methylmercapto-4'- oxoquinazolin-3'-yl) iminoisatin (3) emerged as the most active analogue sh owing anti-MES and anti-PTZ activities better than valproic acid. All the c ompounds showed lower neurotoxicity than phenytoin and carbamazepine.