We propose a six-dimensional framework to calculate the supersymmetric inde
x of M-theory 5-branes wrapped on a six-manifold with product topology M-4
x T-2, where M-4 is a holomorphic 4-cycle in a Calabi-Yau three-fold. This
is obtained by zero-modes counting of the self-dual tensor contribution plu
s "little" string states and correctly reproduces the known results which c
an be obtained by shrinking or blowing the T-2 volume parameter. We also ex
tract the geometric moduli space of the multi M5-brane system and infer the
generic structure of the supersymmetric index for more general geometries.
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