A 25-year longitudinal, comparison study of the outcome of depression

Background. There is still a relative paucity of information about the long -term course of depression. Methods. Consecutive patients admitted to a teaching hospital psychiatry un it with symptoms of depression, previously assessed at 6 months and 2, 5 an d 15 years after index admission, were reviewed at 25 years (N = 49, includ ing eight informants of deceased probands, of an original 145 with major de pression (DEPs)). Prospective psychiatric (N = 22) and retrospective surgic al (N = 50) control groups assessed after 25 years were used for comparison . Results. A further decade of follow-up confirmed the chronicity of depressi on. Of depressed patients (DEPs) followed for the full 25-year-period only 12 % of the 49 original DEPs recovered and remained continuously well, 84 % experienced recurrences, 2 % experienced an unremitting course and another 2 % died by suicide. Note that in the first 15-year-period 6 % (9/145 DEPs ) committed suicide, a further 38 died and 32 were lost to follow-up. They experienced an average of three episodes of depression over the 25 years. I n the decade since the 15-year follow-up, 27 % improved in clinical outcome (including four of five previously chronically depressed patients), 55 % r emained unchanged and 18 % worsened; and the number of episodes per year de clined. Patients initially diagnosed with neurotic or endogenous depression had similar long-term outcomes. The criteria for a current DSM-III-R disor der were met by 37 % of DEPs, including 11 % with depression or dysthymia. On the global assessment of functioning scale 78 % of the DEPs had some imp airment compared to 62 % of psychiatric controls and 40 % of surgical contr ols. Conclusion. Even after 25 years, severe depressive disorders appear to have poor long-term outcomes. Patients with chronic outcomes over 15 years can improve when followed over longer periods.