Apical hypertrophic cardiomyopathy is a disease with clear electrocardiogra
phic and echocardiographic characteristics. However, poor visualization of
apical endocardial border is a limiting factor to diagnose apical hypertrop
hic cardiomyopathy by echocardiography. We present a case report of a patie
nt with a characteristic electrocardiogram but poor apical endocardial bord
er delineation. A contrast-enhanced echocardiography was performed to confi
rm the diagnosis of apical hypertrophic cardiomyopathy. We discuss the role
of echocardiographic image enhancement with contrast to diagnose apical hy
pertrophic cardiomyopathy.