Purpose. - Endothelial and smooth muscle cells interact with each other to
form new blood vessels. In this review, the cellular and molecular mechanis
m underlying the formation of the primary vascular plexus (vasculogenesis),
the sprouting of further blood vessels (angiogenesis) and their maturation
via recruitment of smooth muscle cells (arteriogenesis) during physiologic
al and pathological conditions are summarized.
Current knowledge and key point. - The concept of angiogenesis is studied i
n tumoral and cardiovascular pathology. Promoting the formation of new coll
ateral vessels in ischemic tissues using angiogenic growth factors (therape
utic angiogenesis) is a promising approach in cardiovascular diseases. Conv
ersely, inhibition of the action of key regulators of angiogenesis is a new
pathway for the treatment of solid tumors and metastasis.
Future prospects and projects. - These concepts are being tested now in cli
nical trials in the oncology or cardiovascular fields. Some trials are repo
rted in this review with their potential adverse effects, limits and develo
pments in the future. (C) 2001 Editions scientifiques et medicales Elsevier
SAS.