The T4336C variant is a marker of mitochondrial subhaplogroup H1, a commoncomponent of the Russian and German gene pools

Analysis of mitochondrial. DNA (mtDNA) restriction polymorphism carried out in a sample of Russians from Magadan (n = 150) showed that the frequency o f the +4332AvaII variant (a T-C transition at,nucleotide position 4336) in this population was 4.7%. All +4332AvaII types of mtDNA belonged to the mit ochondrial group H. They were characterized by a back of the AluI restricti on endonuclease site at position 7025. According to hypervariable. segment I sequencing data, they contained the 16304C variant, and thus belong to th e subgroup H1. Thus, the +4332AvaII (T4336C) variant is a marker of the mit ochondrial subgroup III, chiefly occurring in German-speaking populations. Utilization of the H1-mtDNA markers for the investigation of the genetic hi story and the origin of Slavs is discussed.