Natural anti-HIV agents. Part 2: Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata

Authors
Zhang, HJ Tan, GT Hoang, VD Van Hung, N Cuong, NM Soejarto, DD Pezzuto, JM Fong, HHS
Citation
Hj. Zhang et al., Natural anti-HIV agents. Part 2: Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata, TETRAHEDR L, 42(49), 2001, pp. 8587-8591
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
49
Year of publication
2001
Pages
8587 - 8591
Database
ISI
SICI code
0040-4039(200112)42:49<8587:NAAP2L>2.0.ZU;2-5
Abstract
We report herein the first isolation of a novel structural type sesquiterpe ne designated as 'litseane' from the twigs and leaves of Litsea verticillat a Hance (Lauraceae). The isolate (litseaverticillol A, 1) was obtained as a racemate through bioassay-guided fractionation and found to inhibit the re plication of human immunodeficiency virus (HIV) type I with an IC50 value o f 5.0 mug/mL (21.4 muM) and a selectivity index of 2.6. Spectroscopic data and a potential biosynthetic pathway are given. (C) 2001 Elsevier Science L td. All rights reserved.