Total synthesis of variolin B

Authors
Anderson, RJ Morris, JC
Citation
Rj. Anderson et Jc. Morris, Total synthesis of variolin B, TETRAHEDR L, 42(49), 2001, pp. 8697-8699
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
49
Year of publication
2001
Pages
8697 - 8699
Database
ISI
SICI code
0040-4039(200112)42:49<8697:TSOVB>2.0.ZU;2-0
Abstract
The total synthesis of the marine alkaloid variolin B has been achieved in eight steps, starting from commercially available 4-chloro-2-methylthiopyri midine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroace tic acid. (C) 2001 Elsevier Science Ltd. All rights reserved.