Prostate cancer detection with two sets of tencore compared with two sets of sextant biopsies

Objectives. To compare the cancer detection of two consecutive sets of pros tate biopsies using either the sextant or the 10-core technique. Methods. Ninety-one specimens after radical prostatectomy were used and con secutive sets of biopsies were performed ex vivo on each prostate after the operation. The sextant biopsies were taken paramedian and midlobular, thre e per side. For the 10-core biopsies, two cores per side from the lateral a reas of the prostate were added. We developed a realistic simulation of a t ransrectal sonographic biopsy procedure. Results. In the first set of sextant biopsies, 55 prostate cancers (60.4%) were found; in the second set, 13 additional tumors were detected. Two cons ecutive sets of sextant biopsies thus found 68 tumors (74.7%). Using one 10 -core biopsy led to cancer detection in 71 of the prostates (78%). A second 10-core biopsy revealed 11 additional tumors, for a cumulative cancer dete ction rate of 90.1%. We found that 9 (9.9%) of all the cancers were not dia gnosed by two consecutive sets of this extended biopsy protocol. Eight of t hese cancers (88.9%) were clinically significant as determined by a tumor v olume larger than 0.5 cm(3). Conclusions. Although the 10-core protocol is far superior to the commonly used sextant protocol, a significant number of prostate cancers can still b e found on a second similar set of prostate biopsies. Even after two consec utive sets of 10-core biopsies, approximately 10% of the prostate tumors re mained undetected. Most of them were clinically significant. (C) 2001, Else vier Science Inc.