CD1 - The pathology perspective

Authors
Citation
Sm. Rhind, CD1 - The pathology perspective, VET PATH, 38(6), 2001, pp. 611-619
Citations number
56
Categorie Soggetti
Veterinary Medicine/Animal Health","Medical Research Diagnosis & Treatment
Journal title
VETERINARY PATHOLOGY
ISSN journal
03009858 → ACNP
Volume
38
Issue
6
Year of publication
2001
Pages
611 - 619
Database
ISI
SICI code
0300-9858(200111)38:6<611:C-TPP>2.0.ZU;2-T
Abstract
CD1 molecules are a family of cell surface-associated glycoproteins now rec ognized as having a role in antigen presentation. These glycoproteins are d istinct from yet have some similarities to classical major histocompatibili ty complex class I and class H molecules. The role of these molecules has b een studied in detail over recent years, with an explosion of interest foll owing the demonstration that they can present nonprotein antigens to certai n subpopulations of T cells. The purpose of this paper is to provide an ove rview of current knowledge of the function of the CD1 family with specific emphasis on the potential role in the pathogenesis of certain diseases. Alt hough much of the current research in this field has inevitably concentrate d on mice and humans, this work also has potential significance for veterin ary species.