Sm. Agamy et al., Enaminones as building blocks in heterocyclic synthesis: A new one pot synthesis of polyfunctional substituted pyridines, Z NATURFO B, 56(10), 2001, pp. 1074-1078
Citations number
21
Categorie Soggetti
Chemistry
Journal title
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
Enaminones react with a variety of active methyl and methylene reagents in
presence of ammonium acetate to yield functionally substituted pyridines in
good yields. The reaction proceeded via initial Michael addition across th
e double bond followed by cyclization. The reaction of enaminone with aroma
tic aldehyde in acetic acid/ammonium acetate afforded the dihydropyridine t
hat was oxidized to the corresponding pyridine.